Modules
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Topics addressed
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Quiz
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Number of pages
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01-Basic concepts in immunology
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Three lines of defense
Disease-causing agents
Defense against pathogens
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Yes
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53 pages
|
02-Cells of the immune system
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Development, distribution, phenotype, activation & function of:
Neutrophils, Eosinophils, Basophils
Mast cells
Monocytes, Macrophages
Dendritic cells
B and T lymphocytes
Innate lymphoid cells, Natural killer cells
Erythrocytes
Platelets
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Yes
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115 pages
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03-Lymphoid tissues and organs
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Primary lymphoid organs
Bone marrow & Thymus: functional anatomy
Myelopoiesis
Lymphopoiesis
Secondary lymphoid organs
Lymph nodes, spleen, MALT: functional anatomy
Extralymphoid tissues
Skin, Airways, Gut, Urogenital tract: functional anatomy
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Yes
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181 pages
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04-Antigen receptors
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Antigen recognition by T and B cells
B cell receptor
T cell receptor
Immunoglobulin genes
TCR genes
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Yes
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33 pages
|
05-Antigen presentation
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Antigen
Antigen sampling
Antigen presentation
Ag-presenting pathways
Ag-presenting cells
Ag-presenting molecules: MHC & CD1
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Yes
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60 pages
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06-Leukocyte migration
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Molecular mechanisms of cell extravasation
Migratory routes of leukocytes
Chemoattractants
Cell adhesion molecules
Integrins
Selectins
Mucins
CAMs
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Yes
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76 pages
|
07- Innate Immunity
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Defense mechanisms of epithelial linings
Innate immune recognition strategies
Detection of microbes
Detection of missing self
Detection of altered self
Pattern recognition receptors
Soluble PRR
Phagocytic PRR (Scavenger receptors, Mannose receptor)
Signaling PRR (TLRs, NLRs, RLRs)
The complement
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Yes
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62 pages
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08-T cell immunity
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T cell activation
T cell-APC interactions
TCR signaling
T cell differentiation
Conditions of differentiation of CD4 T cells into Th1, Th2, Th17, THF, Treg
Effector T cell functions
CTL, Th1, Th2, Th17, THF, Treg
End of T cell response
T cell exhaustion
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Yes
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54 pages
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09-B cell immunity
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T-cell dependent B cell response
B cell activation
B cell differentiation
Extrafollicular pathway
Germinal center reaction (Affinity maturation, Class switching)
Effector B cell functions
Antibody-mediated functions
Distribution and function of Igs
T-cell dependent B cell response
B cell activation
B1 cells and MZ cells
TI antigens
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Yes
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47 pages
|
10-Immunological memory
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T cell memory
T cell memory subsets
Differentiation pathways
Migratory properties
Maintenance
B cell memory
Memory B cells
Plasma cells
|
No
|
14 pages
|
11-Immunological tolerance
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Central tolerance (mechanisms)
Peripheral tolerance (mechanisms)
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No
|
13 pages
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12-Mucosal immunity
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Mucosal surfaces
Innate and adaptive immunity of the airways
Innate and adaptive immunity of the gut
Control of the microbiota
Innate and adaptive immunity of the genital tract
Innate and adaptive immunity of the urinary tract
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Yes
|
69 pages
|
13-Skin immunity
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Innate and adaptive immunity of the skin
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No
|
12 pages
|
14-Cytokines
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Definition and modes of action
Cytokine families
Cytokine receptors
Signaling pathways
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No
|
76 pages
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